Episodes

  • Clinical Challenges in Transplant Surgery: How Xenotransplantation Will Change Our Lives

    Clinical Challenges in Transplant Surgery: How Xenotransplantation Will Change Our Lives
    Mar 30 2026
    Xenotransplantation—the use of organs from other species to treat human disease—has long existed at the intersection of science fiction and surgical innovation. While early efforts were marked by limited success and ethical controversy, recent advances in genetic engineering, immunosuppression, and organ preservation have brought the field closer than ever to clinical reality.In this episode of Behind the Knife, we are joined by Dr. Joshua Mezrich to explore the history, science, and future of xenotransplantation. Through a narrative lens, we trace the evolution of transplantation from its earliest experimental days to the modern era of gene-edited porcine organs, highlighting key breakthroughs, ethical challenges, and the pioneers who shaped the field. We also examine the current state of clinical trials and what xenotransplantation may mean for the future of organ availability and transplant practice.Hosts - Madeline Cloonan, MD PhD, General Surgery Resident, University of Nebraska Medical Center, @maddie_cloonan - Joshua Mezrich, MD, Professor, University of Wisconsin School of Medicine and Public HealthLearning Objectives By the end of this episode, listeners will be able to:- Describe the historical evolution of xenotransplantation, including the primate and early porcine eras - Explain the key immunologic and biologic barriers to xenotransplantation, including hyperacute rejection and the role of natural antibodies - Summarize major scientific advances that enabled modern xenotransplantation, including cloning and CRISPR-based gene editing - Discuss recent clinical experiences and ongoing trials of xenotransplantation in humans - Evaluate the ethical considerations and societal implications of xenotransplantation - Consider the potential role of xenotransplantation in addressing organ shortage and reshaping transplant eligibility and allocationCheck out Dr. Mezrich’s new book! https://www.amazon.com/Every-Living-Creature-Xenotransplantation-Change-ebook/dp/B0FH14LF6K***Fellowship Application Link: https://forms.gle/QSUrR2GWHDZ1MmWC6***Surgical Instrument FlashCards: https://app.behindtheknife.org/premium/surgical-instrument-flashcards Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium:General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US
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    46 mins
  • OBGYN Oral Board Review - Sample Episode: Adnexal Emergency

    OBGYN Oral Board Review - Sample Episode: Adnexal Emergency
    Mar 27 2026

    INTRODUCING Behind the Knife OBGYN Oral Board Review!

    The oral boards aren't just about knowledge—they are about executing under pressure. This course is designed to give you the structure and confidence to command the room. We have curated 98 high-yield scenarios covering the "Big Three" of the exam: Obstetrics, Gynecology, and Office Practice. Whether it’s a surgical emergency or a complex clinic workup, we will walk you through exactly how to articulate your plan, defend your decisions, and pass this exam.

    Each scenario includes 2 parts. The first part is a perfectly executed scenario. If you are able to achieve this level of performance in your preparation you are sure to pass the oral exam with flying colors. The second part introduces high-yield commentary to each scenario. This commentary includes tips and tricks to help you dominate the most challenging scenarios in addition to practical, easy-to-understand teaching that covers the most confusing topics. We are confident you will find this unique, dual format approach a highly effective way to prepare for the test.

    Please check out the preview episodes below that include Parts A and B, with and without commentary.

    This course includes access to our Oral Board Simulator. Step into the hot seat and experience the pressure of the real exam and receive detailed, actionable feedback with the most advanced oral board prep available.

    • 3-Month Purchase - 10 exams
    • 6-Month Purchase - 22 exams
    • 12-Month Purchase - 46 exams

    Learn More: https://app.behindtheknife.org/premium/obgyn-oral-board-review

    DOMINATE THE DAY!
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    20 mins
  • The Prelim Playbook: Tips, Tricks, and Unspoken Rules for Success

    The Prelim Playbook: Tips, Tricks, and Unspoken Rules for Success
    Mar 26 2026

    In this episode, we explore the grueling realities of the general surgery preliminary year—a high-stakes, one-year audition for surgical trainees operating without a safety net. We sit down with a program director, a former IMG prelim turned attending, and a recently successful SOAP applicant to uncover exactly what it takes to survive the scramble and excel clinically. Listen in to learn actionable strategies for navigating hospital expectations, securing vital mentorship, and ultimately turning your preliminary position into a secured categorical spot.

    Hosts:

    Ayman Ali, MD
    Dr. Ayman Ali is a Behind the Knife fellow and general surgery PGY-4 at Duke Hospital.

    Kevin Naresh Shah, MD
    Dr. Kevin Shah is an Assistant Professor of Hepatobiliary Surgery at the Duke University School of Medicine and Program Director of General Surgery.

    Katharine Louise Jackson, MBBS
    Dr. Louise Jackson is an Assistant Professor of Colon and Rectal Surgery at the Duke University School of Medicine and the Medical Student Clerkship Director.

    Rafael Felix Tiongco, MD
    Dr. Rafael Tiongco is a first-year resident at Penn State College of Medicine.

    Sponsor Disclaimer: Visit goremedical.com/btkpod to learn more about GORE® SYNECOR Biomaterial, including supporting references and disclaimers for the presented content. Refer to Instructions for Use at eifu.goremedical.com for a complete description of all applicable indications, warnings, precautions and contraindications for the markets where this product is available. Rx only

    ***Fellowship Application Link: https://forms.gle/QSUrR2GWHDZ1MmWC6

    Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.
    If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen
    Behind the Knife Premium:
    General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review
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    Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship
    Dominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotation
    Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review
    Colorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-review
    Surgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-review
    Cardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-review
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    54 mins
  • Clinical Challenges in Hepatobiliary Surgery: Pancreatic Cysts

    Clinical Challenges in Hepatobiliary Surgery: Pancreatic Cysts
    Mar 23 2026
    Identification of pancreatic cystic lesions has become increasingly common due to improved resolution and increased utilization of cross-sectional imaging. However, there are many types of pancreatic cysts, each with varying degrees of malignant potential. In this episode from the HPB team at Behind the Knife, listen in as we discuss the clinical presentation, diagnostic work-up, and management strategies for various pancreatic cysts: Pseudocysts, Serous Cystadenomas, Mucinous Cystic Neoplasms, and IPMNs, amongst others. HostsAnish J. Jain MD (@anishjayjain) is a current PGY4 General Surgery resident at Stanford University and a former T32 Research Fellow at the University of Texas MD Anderson Cancer Center.Jon M. Harrison MD is a Hepatobiliary & Pancreatic (HPB) surgeon at the Massachusetts General Hospital in Boston, MA and a former HPB Surgery fellow at Stanford University. Learning Objectives· Develop an understanding of the clinical presentation, diagnostic work-up, and treatment of benign pancreatic cysts· Develop an understanding of the clinical presentation, diagnostic work-up, and treatment of pre-malignant pancreatic cysts· Develop an understanding of when surveillance is appropriate for management of pancreatic cysts, and the criteria involved in making that determination· Develop an understanding of the prognostic utility of PancSeq for IPMNsReferences:Paniccia A, Polanco PM, Boone BA, et al. Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts. Gastroenterology. 2023 Jan;164(1):117-133.e7.PubMed Link: https://pubmed.ncbi.nlm.nih.gov/36209796/ Ohtsuka T, Fernandez-Del Castillo C, Furukawa T, et al. International evidence-based Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas. Pancreatology. 2024 Mar;24(2):255-270.PubMed Link: https://pubmed.ncbi.nlm.nih.gov/38182527/ Zelga P, Hernandez-Barco YG, Qadan M, et al. Number of Worrisome Features and Risk of Malignancy in Intraductal Papillary Mucinous Neoplasm. J Am Coll Surg. 2022 Jun 1;234(6):1021-1030.PubMed Link: https://pubmed.ncbi.nlm.nih.gov/35703792/ Ciprani D, Weniger M, Qadan M, et al. Risk of malignancy in small pancreatic cysts decreases over time. Pancreatology. 2020 Sep;20(6):1213-1217.PubMed Link: https://pubmed.ncbi.nlm.nih.gov/32819844/ ***Fellowship Application Link: https://forms.gle/QSUrR2GWHDZ1MmWC6Sponsor Disclaimer: Visit goremedical.com/btkpod to learn more about GORE® SYNECOR Biomaterial, including supporting references and disclaimers for the presented content.Refer to Instructions for Use at eifu.goremedical.com for a complete description of all applicable indications, warnings, precautions and contraindications for the markets where this product is available. Rx only Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium:General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US
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    38 mins
  • Clinical Challenges in Colorectal Surgery: Management of Metastatic Colorectal Cancer

    Clinical Challenges in Colorectal Surgery: Management of Metastatic Colorectal Cancer
    Mar 19 2026
    With the increasing incidence of colorectal cancer in those less than 50 years of age, one must wonder how many patients present with a Stage IV diagnosis. Take a deep dive with us discussing the management of metastatic colorectal cancer by joining our team and guests, Drs. Cathy Eng, Michael D’Angelica, and Nina Sanford.Hosts: - Dr. Janet Alvarez - General Surgery Resident at New York Medical College/Metropolitan Hospital Center- Dr. Wini Zambare – General Surgery Resident at Weill Cornell Medical Center/New York Presbyterian- Dr. Philip Bauer, Assistant Professor of Surgery, Division of Colon and Rectal Surgery, The Ohio State University Wexner Medical Center, Arthur G. James Cancer Hospital- Dr. J. Joshua Smith MD, PhD, Chair, Department of Colon and Rectal Surgery at MD Anderson Cancer Center Guest Speakers:- Dr. Michael D’Angelica MD, FACS – Hepatopancreatobiliary Surgery, Memorial Sloan Kettering Cancer Center, Enid A. Haupt Chair in Surgery, Vice Chair, Education- Dr. Cathy Eng MD, FACP - Division of Hematology and Oncology, Vanderbilt-Ingram Cancer Center, David H. Johnson Endowed Chair in Surgical and Medical Oncology, Professor of Medicine, Hematology and Oncology, VICC Associate Director for Strategic Relations and Research Partnerships, Executive Director, Young Adult Cancers Program - Dr. Nina Sanford, MD – Radiation Oncology, UT Southwestern Medical Center, Chief of Gastrointestinal Radiation Oncology Service, Associate Professor Learning Objectives:1. Review the epidemiology, prognosis, and common metastatic patterns of metastatic colorectal cancer (mCRC).2. Discuss the role of systemic chemotherapy and targeted therapies in the first- and subsequent-line treatment of mCRC, including the impact of molecular biomarkers such as MSI/MMR, RAS, BRAF, and HER2.3. Evaluate the indications and timing of surgical and locoregional therapies for metastatic colorectal cancer, particularly in patients with liver-limited or oligometastatic disease.4. Describe the multidisciplinary management of mCRC, including the roles of radiation therapy, systemic therapy sequencing, and palliative interventions to optimize outcomes and quality of life.References:Singh, M., Morris, V. K., Bandey, I. N., Hong, D. S. & Kopetz, S. Advancements in combining targeted therapy and immunotherapy for colorectal cancer. Trends Cancer 10, 598–609 (2024). PubMed Link: https://pubmed.ncbi.nlm.nih.gov/38821852/Napolitano, S. et al. BRAFV600E mutant metastatic colorectal cancer: Current advances in personalized treatment and future perspectives. Cancer Treat. Rev. 134, (2025). PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40009904/Ciardiello, F. et al. Clinical management of metastatic colorectal cancer in the era of precision medicine. CA. Cancer J. Clin. 72, 372–401 (2022). PubMed Link: https://pubmed.ncbi.nlm.nih.gov/35472088/Kim, S. Y. & Kim, T. W. Current challenges in the implementation of precision oncology for the management of metastatic colorectal cancer. ESMO Open 5, e000634 (2020). PubMed Link: https://pubmed.ncbi.nlm.nih.gov/32188714/Biller, L. H. & Schrag, D. Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review. JAMA 325, 669–685 (2021). PubMed Link: https://pubmed.ncbi.nlm.nih.gov/33591350/Smith, J. J. et al. Genomic stratification beyond Ras/B-Raf in colorectal liver metastasis patients treated with hepatic arterial infusion. Cancer Med. 8, 6538–6548 (2019). PubMed Link: https://pubmed.ncbi.nlm.nih.gov/31503397/Saadat, L. V. et al. Hepatic Artery Infusion Chemotherapy Compared to Transarterial Radioembolization For Unresectable Colorectal Liver Metastases. Ann. Surg. 10.1097/SLA.0000000000006851 doi:10.1097/SLA.0000000000006851. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/?term=10.1097/SLA.0000000000006851 (Linked via DOI search as the direct PMID is still indexing)Xiao, A. & Fakih, M. KRAS G12C Inhibitors in the Treatment of Metastatic Colorectal Cancer. Clin. Colorectal Cancer 23, 199–206 (2024). PubMed Link: https://pubmed.ncbi.nlm.nih.gov/38825433/André, T. et al. Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer. N. Engl. J. Med. 383, 2207–2218 (2020). PubMed Link: https://pubmed.ncbi.nlm.nih.gov/33264544/Morris, V. K. et al. Treatment of Metastatic Colorectal Cancer: ASCO Guideline. J. Clin. Oncol. 41, 678–700 (2023). PubMed Link: https://pubmed.ncbi.nlm.nih.gov/36252154/Xu, Z. et al. Treatments for Stage IV Colon Cancer and Overall Survival. J. Surg. Res. 242, 47–54 (2019). PubMed Link: https://pubmed.ncbi.nlm.nih.gov/31071604/Smith, J. J. & D’Angelica, M. I. Surgical Management of Hepatic Metastases of Colorectal Cancer. Hematol. Oncol. Clin. North Am. 29, 61–84 (2015). PubMed Link: https://pubmed.ncbi.nlm.nih.gov/25475573/Strickler, J. H. et al. Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre...
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    46 mins
  • Healthcare Econ 101 - Ep. 3: Decoding the Black Box (Billing & Coding)

    Healthcare Econ 101 - Ep. 3: Decoding the Black Box (Billing & Coding)
    Mar 16 2026

    In the final installment of the Healthcare Econ 101 miniseries, Dr. Christopher Childers and Dr. Nina Clark demystify the "black box" of medical billing and coding. This episode breaks down the two essential components of every medical bill: ICD codes, which identify the patient's diagnosis (the "why"), and CPT codes, which describe the specific services or procedures performed (the "what"). The discussion emphasizes that surgeons are legally and ethically responsible for the accuracy of these codes, regardless of whether a professional coder or an automated system handles the data entry. Listeners will gain insights into the "Global Period," the pitfalls of illegal "unbundling," and how to use modifiers—such as the -22 for increased procedural services—to accurately reflect the complexity of a case.

    ***Fellowship Application Link: https://forms.gle/QSUrR2GWHDZ1MmWC6

    Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.
    If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen
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    Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review
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    40 mins
  • Healthcare Econ 101 - Ep. 2: Show Me the Money (RVUs & DRGs)

    Healthcare Econ 101 - Ep. 2: Show Me the Money (RVUs & DRGs)
    Mar 12 2026

    Ever wonder why a complex gallbladder surgery only nets the surgeon about $350, while the hospital collects thousands? In this episode, Dr. Christopher Childers and Dr. Nina Clark pull back the curtain on how the money actually flows in medicine. From the birth of the RVU to the "Two Midnight Rule," we’re breaking down the math behind your paycheck.

    Next Step: Ready to make sure you're actually getting credit for the work you do? Join us for Episode 3, where we dive into the "Black Box" of Coding and Billing.

    ***Fellowship Application Link: https://forms.gle/QSUrR2GWHDZ1MmWC6

    Sponsor Disclaimer: Visit goremedical.com/btkpod to learn more about GORE® SYNECOR Biomaterial, including supporting references and disclaimers for the presented content. Refer to Instructions for Use at eifu.goremedical.com for a complete description of all applicable indications, warnings, precautions and contraindications for the markets where this product is available. Rx only

    Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.
    If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen
    Behind the Knife Premium:
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    49 mins
  • Healthcare Econ 101 - Ep. 1: The Language of Money & Insurance Structures

    Healthcare Econ 101 - Ep. 1: The Language of Money & Insurance Structures
    Mar 9 2026

    Ever feel like you’re fluent in medical jargon but totally illiterate when it comes to the business side of surgery? You’re not alone. In this series premiere, Dr. Christopher Childers (Surgical Oncologist and health policy expert) joins Dr. Nina Clark to demystify the "second world" of medicine: healthcare finance. We’re breaking down the basic vocabulary every surgeon needs to advocate for themselves and their patients.

    Next Step: Ready to see how this translates to your paycheck? In Episode 2, we dive into Physician and Hospital Compensation, RVUs, and the flow of funds.

    ***Fellowship Application Link: https://forms.gle/QSUrR2GWHDZ1MmWC6

    Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.
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    Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review
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    1 hr