This episode is essential for millions of women who’ve been on antidepressants for years or even decades. Dr. Mark Horowitz, a British-Australian psychiatry researcher, neuroscientist, and lead author of clinical deprescribing guidelines, offers an honest conversation about the science, marketing myths, and long-term effects of antidepressants, including emotional numbing, weight gain, disrupted sleep, and cognitive changes. Dr. Horowitz explains the difference between addiction and physical dependence, why withdrawal symptoms are often mistaken for relapse, and the evidence-based method of hyperbolic tapering.

Whether you’ve been on an antidepressant for two years or twenty, you’ll leave with smart questions for your prescriber, a clear sense of your own readiness, and reassurance that tapering off slowly and carefully has a success rate of over 90%.

Episode Overview:
(0:00) Intro/Teaser
(6:00) Midlife Misdiagnosis
(11:00) How Life Events Became Medicalized and Why That Matters
(18:00) Long-Term Side Effects
(27:00) The Serotonin Hypothesis
(31:00) Addiction vs. Physical Dependence
(39:00) Withdrawal vs. Relapse: How to Tell the Difference
(49:00) Hyperbolic Tapering Explained
(57:00) How to Know if You're Ready to Come Off Your Antidepressant
(1:10:00) What to Say to Your Doctor
(1:17:00) The After-Party with Dr. Stephanie

Resources mentioned: https://drstephanieestima.com/podcasts/ep461

We couldn’t do it without our sponsors:

HIGHER DOSE - If you’re noticing thinning, shedding, or simply want to support scalp and hair health proactively, this is a powerful addition to your routine. Get 15% off at https://higherdose.com with code BETTER at checkout.

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P.S. When you're ready, here are two ways Dr. Stephanie can help you:

Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.

Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Neuroscientist Dr. Tommy Wood breaks down what it actually takes to keep your brain sharp as you age. Drawing from his new book The Stimulated Mind, Tommy makes the case that movement is non-negotiable for brain health — and that even small amounts make a meaningful difference. From walking and resistance training to dancing and pickleball, different types of exercise protect different parts of the brain in ways that compound over time. The bottom line? You don't need a perfect plan. You just need to start.

Episode Overview:
(0:00) Intro/Teaser
(7:00) The Exercise Framework: From Snacks to Sprints
(11:00) The Norwegian 4x4 Study
(14:00) Lactate, BDNF & Why HIIT Is Good for Your Brain
(15:00) Resistance Training, White Matter & Decision-Making Speed
(17:00) Why Pickleball Beats the Recumbent Bike
(24:00) Stress, Cortisol & Inflammation
(31:00) Muscle as a Proxy for Brain Health
(40:00) Nutrition for Brain Health
(53:00) The Female Brain
(1:09:00) Brain Training: Languages, Video Games & the Power of Failing
(1:23:00) The After-Party with Dr. Stephanie

Resources mentioned in this episode: https://drstephanieestima.com/podcasts/ep460

We couldn’t do it without our sponsors:

PIQUE - Designed to deeply hydrate, enhance skin elasticity & firmness and support sustained energy—exactly what we need during this stage of life. Start your daily ritual today with 20% off for life—plus a free gift to elevate your routine. Head to https://piquelife.com/drestima.

COZY EARTH - Cozy Earth helps you feel better by keeping your temperature perfect overnight to facilitate deep restorative sleep. Head to https://cozyearth.com and use my code BETTER for up to 20% off.

KENETIK - You think carefully about how you fuel your body but are you fueling your brain? Learn more about Kenetik and try it for yourself by going to https://drinkkenetik.com/BETTER and use code BETTER for 15% off your purchase.

HIGHER DOSE - If you’re noticing thinning, shedding, or simply want to support scalp and hair health proactively, this is a powerful addition to your routine. Get 15% off the Red Light Hat at https://higherdose.com with code BETTER at checkout.

MINI PAUSE - Join my weekly roundup of the BEST actionable steps for women 40+ who want to gain control of their hormones during perimenopause and menopause. Head over to https://drstephanieestima.com/newsletter/ to sign up now!

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P.S. When you're ready, here are two ways Dr. Stephanie can help you:

Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.

Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Your keys aren't lost. Your mind isn't going. And no, that's not Alzheimer's. Dr. Majid Fotuhi, Adjunct Professor, Johns Hopkins University & author of The Invincible Brain, busts the biggest myth in women's brain health: that the fog, the forgetfulness, and the "wait, why did I walk in here?" moments of perimenopause are a sign of something sinister. Spoiler: they're not. And your brain? It can literally grow.

From the surprising science of how walking three times a week can give you a measurably bigger brain, to why your hearing aid might be the best thing you ever do for your memory, Dr. Fotuhi gives us proof that midlife isn't a decline — it's a new childhood. And this time, you're in charge.

Episode Overview (timestamps are approximate):
(0:00) Intro/Teaser
(5:00) Why Perimenopause Causes Brain Fog
(8:00) Estrogen & How Hormones Affect Memory
(13:00) Exercise Is the #1 Pillar of Brain Health
(16:00) Exercise That Grows Your Brain
(21:00) Brain Fog vs. Alzheimer’s
(26:00) Your Genes Are Not Your Destiny
(30:00) Medications & Hearing Loss
(43:00) Beyond IQ: The 30 Forms of Intelligence
(50:00) Brain Training & Neuroplasticity
(1:01:00) The After-Party with Dr. Stephanie

Resources mentioned in this episode: https://drstephanieestima.com/podcasts/ep458

We couldn’t do it without our sponsors:

QUALIA CREATINE+ - If you want to feel stronger, sharper, and more resilient, Qualia’s Creatine+ is my recommendation.Go to https://qualialife.com/better and use code BETTER to save up to 50%, plus an additional 15% off.

COZY EARTH - Cozy Earth helps you feel better by keeping your temperature perfect overnight to facilitate deep restorative sleep. Head to https://cozyearth.com and use my code BETTER for up to 20% off.

TROSCRIPTIONS - There’s a completely new way to optimize your health. Give it a try at https://troscriptions.com/BETTER or enter BETTER at checkout for 10% off your first order.

PIQUE LIFE - If you want to redefine your evening ritual and still feel like yourself the next day, you can get 10% off for life. Yes, for life at https://piquelife.com/better

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P.S. When you're ready, here are two ways Dr. Stephanie can help you:

Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.

Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Dr. Maria Sophocles examines the “bedroom gap,” the disparity in sexual expectations and challenges between men and women in midlife. In this episode, she explains how menopausal hormonal changes, together with psychological and cultural pressures, affect women’s sexual agency. Many women internalize norms that prioritize a partner’s needs over their own, leading to shame about reduced libido. This conversation is a call to action for women to prioritize their sexual health and engage in honest dialogue to support healthier, more fulfilling relationships.

Episode Overview (timestamps are approximate):
(0:00) Intro/Teaser
(5:00) The Bedroom Gap
(10:00) Hormones & The Neiman Marcus to IKEA Transition
(14:00) Systemic Estrogen vs. Vaginal & The Cancer Fear
(23:00) Hormone Therapy & The Healthy User Bias
(26:00) Non-Hormonal Options
(32:00) Sex After a Heart Attack
(40:00) Sex Span as Health Span
(42:00) Why Women Think Sex Is For Men
(49:00) Where to Learn About Sex
(55:00) How to Talk to Your Partner
(1:10:00) Redefining Sex at Any Age
(1:13:00) After Party with Dr. Stephanie

Resources mentioned can be found at https://drstephanieestima.com/podcasts/ep456

We couldn’t do it without our sponsors:

KENETIK - You think carefully about how you fuel your body but are you fueling your brain? Learn more about Kenetik and try it for yourself by going to https://drinkkenetik.com/BETTER and use code BETTER for 15% off your purchase.

MUSE - Train your nervous system with feedback, the same way you’d train muscles with resistance. If you are ready to unlock your brain's potential, go to https://choosemuse.com/BETTER or use code BETTER at checkout to get started.

COZY EARTH - Cozy Earth helps you feel better by keeping your temperature perfect overnight to facilitate deep restorative sleep. Head to https://cozyearth.com and use my code BETTER for up to 20% off.

PIQUE LIFE - If you want to redefine your evening ritual and still feel like yourself the next day, you can get 10% off for life. Yes, for life at https://piquelife.com/better

****************************
P.S. When you're ready, here are two ways Dr. Stephanie can help you:

Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.

Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Ready for the breast health conversation nobody's having? Harvard-trained breast radiologist Dr. Lilian Ebuoma gives a masterclass that covers everything from why your daughter might be developing breast buds at 7 (spoiler: it's not just you) to the real deal on mammograms, dense breasts, and that one lifestyle change that drops breast cancer risk by 25%. Whether you're navigating perimenopause, worried about lumps, confused about nipple discharge colours (yes, there's a rainbow), or just want to understand your breasts better—this episode gives you the knowledge and confidence to advocate for yourself.

Plus, Dr. Lilian shares the one question that transforms patient care and builds trust across cultural divides. If you own breasts or care about someone who does, press play.

Episode Overview (timestamps are approximate):
(0:00) Intro/Teaser
(4:00) Breast Development
(12:00) Breast Pain: Cyclical vs Non-Cyclical
(16:00) Lumps & Self-Exams
(27:00) Nipple Discharge
(33:00) Mastitis
(38:00) Dense Breasts & Mammography Myths
(41:00) Compression, Radiation & Mammograms
(54:00) Lifestyle as Prevention
(58:00) Finding Joy in Movement
(1:05:00) Building Trust Across Cultural Divides
(1:09:00) “What Are You Afraid Of?”
(1:11:00) The After-Party with Dr. Stephanie

Resources mentioned in this episode can be found at: https://drstephanieestima.com/podcasts/ep455

We couldn’t do it without our sponsors

BON CHARGE - Achieve glowing skin, gain more energy, and uplevel your recovery practice with a suite of red light products. Get 15% off at https://boncharge.com/better with code BETTER.

JUST THRIVE HEALTH - Take the Just Thrive FEEL BETTER challenge today, and save 20% on your first order. Go to https://justthrivehealth.com/better and use the code BETTER to see the difference for yourself or get a full product refund, no questions asked.

TIMELINE - As perimenopausal women, we know we are in a fight against time to preserve our muscle strength and endurance, plus our recovery needs are greater. That's why you save 20% at https://timelinenutrition.com/better with code BETTER.

COZY EARTH - Cozy Earth helps you feel better by keeping your temperature perfect overnight to facilitate deep restorative sleep. Head to https://cozyearth.com and use my code BETTER for up to 20% off.

AG1 - Subscribe today to get a 1-month supply of AG Omega-3 with your first AG1 order! You’ll also get their Welcome Kit with everything you need to get you started. Get it now at https://drinkag1.com/stephanie.

****************************
P.S. When you're ready, here are two ways Dr. Stephanie can help you:

Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.

Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Dr. Doug Lucas, a double board-certified orthopedic surgeon and osteoporosis specialist, who dives into the secrets of maintaining optimal bone health. In this episode, you will discover why bone health is vital for women of all ages and learn actionable tips to build and maintain strong bones from your teens to your golden years. Brace yourself for intriguing insights, such as the surprising benefits of prunes as an independent intervention for osteoporosis! This episode is a comprehensive guide to nurturing your bones through diet, exercise, and hormonal balance.

Episode Overview [Timestamps are approximate]:
(0:00) Introduction
(4:00) Why Women Get Osteoporosis in Their 40s
(11:00) The Chronic Dieting Problem & Under-Eating Epidemic
(17:00) Pregnancy, Breastfeeding & Bone Density
(23:00) Hormones Explained
(34:00) Nutrition for Bone Health
(43:00) The Boron Secret & Prunes for Bone Density
(47:00) Exercise That Hurts Your Bones
(55:00) How to Lift Weights for Bone Health
(1:04:00) Weighted Vests, GLP-1s & Bone Medications
(1:23:00) The After-Party with Dr. Stephanie

Resources mentioned in this episode can be found at https://drstephanieestima.com/podcasts/ep454

We couldn’t do it without our sponsors:

TROSCRIPTIONS - There’s a completely new way to optimize your health. Give it a try at https://troscriptions.com/BETTER or enter BETTER at checkout for 10% off your first order.

PIQUE LIFE - If you want to redefine your evening ritual and still feel like yourself the next day, you can get 10% off for life. Yes, for life at https://piquelife.com/better

YOUNG GOOSE - Youth Serum & Youth Moisturizer from Young Goose is designed to support NAD⁺-dependent cellular pathways in the skin. Go to https://younggoose.com/better and use code BETTER for 10% off your first purchase

LIFT - If you want muscle for longevity, clarity, and confidence—come LIFT with me. Head over to https://drstephanieestima.com/lift and join today.

QUALIA NAD+ - Boost energy, DNA health, and cellular protection. Save 15% at https://qualialife.com/better with code BETTER.

****************************
P.S. When you're ready, here are two ways Dr. Stephanie can help you:

Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.

Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.