CD19 x CD3 BiTEs for Acute Lymphoblastic Leukemia — An Interview with Dr Bijal Shah

Featuring an interview with Dr Bijal Shah, including the following topics:

• Advent and importance of blinatumomab in the therapeutic landscape of acute lymphoblastic leukemia (ALL) (0:00)
• Similarities and differences between bispecific T-cell engagers (BiTEs) and bispecific antibodies (5:51)
• Rationale underlying the development of surovatamig and MK-1045; benefits of blinatumomab for patients without detectable minimal residual disease (9:56)
• Extramedullary ALL, including in the CNS (13:32)
• Key principles in the development and use of surovatamig and MK-1045, including structural features and recent efficacy and safety findings (18:34)
• Ongoing immunotherapy trials for ALL, including studies of BiTEs and chimeric antigen receptor T-cell therapy (25:37)
• Case: A woman in her late 50s with newly diagnosed Philadelphia chromosome-positive B-cell ALL and multiple comorbidities (31:48)
• Case: A woman in her early 50s with newly diagnosed B-cell ALL, a TP53 mutation and significant extramedullary disease including the CNS (41:16)
• Case: A man in his early 50s with intermediate-risk B-cell ALL who receives surovatamig on a clinical trial (53:05)

CME information and select publications