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Sage Journals Podcast

Sage Journals Podcast

By: SAGE Publishers
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SAGE Publishers Hygiene & Healthy Living Physical Illness & Disease
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  • Therapeutic Advances in Cardiovascular Disease

    Therapeutic Advances in Cardiovascular Disease
    Feb 27 2026
    Proteins are biological machines in living things. A protein called transthyretin, abbreviated as “TTR”’, normally flows in blood to move certain chemicals from one place to another. For normal function, 4 copies of TTR need to be folded together in a specific way. If TTR becomes unfolded or folds the wrong way, it will clump with other TTR proteins. These clumps stick to organ tissues and build up over time. As the sticky clumps grow, they prevent the organs from working properly. When this happens in the heart, it can lead to a weakened heart muscle and eventually death. Acoramidis is a drug that keeps the 4 copies of TTR together and folded correctly. In this medical study, doctors looked at the amount of TTR in the blood of 557 people with misfolded TTR. They found treatment with acoramidis quickly increased the amount of TTR in blood, which lowered the risk of death by more than one-fourth.

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    8 mins
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