In this episode of ICChat, Dr. Ashish Pershad MD MS reviews and critiques the CHAMPION‑AF trial comparing Watchman Flex left atrial appendage occlusion to DOACs for atrial fibrillation. He explains the trial design, endpoints, and statistical choices, and contrasts the published results with real‑world implications.

The episode highlights concerns about non‑inferiority margins, excluded procedural bleeding, lower than expected event rates, and the importance of shared decision making when considering LAAO versus lifelong anticoagulation.

Critical appraisal of the 6-year Evolut low risk trial data and a one on one with Steve Yakubov one of the senior authors on the paper for his take on TAVR adoption in low-risk patients

Appraisal of the SHORTCUT and VICTORY trials comparing IVL to CB and OPN balloons plus a bonus interview with Ajay Kirtane MD deconstructing the trials

A critical appraisal of the CREST 2 clinical trial 4-year outcomes comparing carotid revascularization with current medical therapy in asymptomatic patients with high grade carotid artery stenosis.

A critical appraisal of ENCIRCLE and a follow up interview with Encircle Co-PI David Daniels MD make for an interesting episode.

A Critical appraisal of dedicated TAVR valve trials for AI and a general overview of the status of AI treatment in 2025.

A deep dive into bicuspid aortic valve stenosis and the choice of BEV vs SEV- A propensity matched observational study critically appraised.

A deep dive into 2 network metanalysis looking at IVI in contemporary PCI.