How do we know what we know? That's where science comes in—it gives us a method for testing our ideas and getting trustworthy results. But some researchers have warned that many scientific studies can't be replicated.

To find out how deep the problem goes, the US Defense Advanced Research Projects Agency funded one of the largest analyses of social science, called the SCORE project. They checked the results of thousands of papers across economics, education, and psychology—and found that only half of them could be replicated.

Joining Host Ira Flatow to discuss the findings are Tim Errington, one of the leads on this project, and economist Abel Brodeur, who recently released the results of a separate replication study that found more encouraging results than SCORE did.

Guest:

Dr. Tim Errington is senior director of research at the Center For Open Science in Washington, D.C.

Dr. Abel Brodeur is a professor of economics at the University of Ottawa and founder of the Institute for Replication.

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Movies may be a largely visual medium, but sound plays a huge role in setting tone, creating new worlds, and fleshing out characters. Sound designer Erik Aadahl has brought some of Hollywood’s iconic creatures to life with sound, like the Transformers, 2014’s Godzilla, and Rocky the alien from “Project Hail Mary.” He joins Flora to talk about the science of sound design, and how he uses his background in biology to look for sounds in the animal kingdom.

Guest:

Erik Aadahl is a sound designer and editor at E² in Los Angeles, California.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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GLP-1 drugs like Ozempic, Wegovy, and Zepbound are prescribed for weight loss, diabetes, and blood-sugar management. But as more people use them, patients are reporting a decrease in cravings for drugs and alcohol. Researchers are now investigating whether GLP-1s might be effective for treating alcohol and drug addiction.

How much do we know? What are the risks? And do these drugs tell us anything new about the biology of addiction?

Host Flora Lichtman talks with neuroscientist Joseph Schacht, who is conducting a clinical trial on GLP-1s and alcohol use; and Sarah Carstens, addictions clinical director of Outpatient Services at Penn Medicine’s Princeton House Behavioral Health.

Guests:

Dr. Joseph Schacht is the co-director of the Division of Addiction Science, Prevention, and Treatment at the University of Colorado Anschutz School of Medicine.

Sarah Carstens is the addictions clinical director of Outpatient Services at Penn Medicine’s Princeton House Behavioral Health.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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