Episodes

  • This Popular Fat Loss Shortcut Destroys Your Youth : 1437

    This Popular Fat Loss Shortcut Destroys Your Youth : 1437
    Mar 24 2026
    Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actually is. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Get 20% off your next purchase of OMNi-BiOTiC with code ‘Dave20’ at: https://omnibioticlife.com/ In this episode, Host Dave Asprey and microbiome expert Hannah Kleinfeld break down the hidden gut science behind GLP-1 drugs, ADHD, HRV, histamine intolerance, SIBO, and why most probiotics you're taking are probably dead before they even reach your intestines. Hannah Kleinfeld is the co-founder and COO of Omni-Biotic US, a Yale and Harvard graduate, and a certified health coach whose personal battle with Lyme disease drove her deep into functional medicine and microbiome science. Omni-Biotic is the number one probiotic brand in Europe, used in hospital systems alongside antibiotic treatment, and is now bringing that clinical-grade research to the US market. Dave and Hannah go deep on the gut-brain axis, the vagus nerve, and how dysbiosis drives everything from brain fog and poor sleep optimization to inflammation, metabolic dysfunction, and compromised mitochondria. They cover how GLP-1 drugs slow gut transit time and trigger secondary dysbiosis, why most capsule probiotics rehydrate in stomach acid and fail, how short-chain fatty acids like butyrate cross the blood-brain barrier to regulate neuroinflammation, and how your gut bacteria directly control your heart rate variability, hormones, libido, and skin. This is biohacking your biology from the inside out, and it goes far deeper than supplements and fasting. You'll Learn: Why GLP-1 drugs like Ozempic create secondary dysbiosis and what to do about it How gut inflammation suppresses HRV, disrupts sleep, and accelerates aging Why most probiotics rehydrate in stomach acid and never make it to your intestines The gut-brain connection behind ADHD, brain fog, anxiety, and mood disorders How dysbiosis sabotages weight loss by skewing Firmicutes to Bacteroidetes ratios What the vagus nerve has to do with stress resilience and mitochondria health How to support your microbiome through antibiotics, travel, and SIBO recovery The histamine problem hiding inside popular probiotic strains Why the first 1,000 days of a baby's life shape lifelong immunity and HPA axis function How targeted probiotic formulations are changing functional medicine Thank you to our sponsors! Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayPre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference Fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVEBrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power BundleDave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Hannah Kleinfeld, Omni-Biotic, gut microbiome, probiotics that work, GLP-1 gut damage, Ozempic side effects, secondary dysbiosis, gut brain axis, vagusnerve HRV, SIBO treatment, histamine intolerance probiotics, leaky gut inflammation, butyrate blood brain barrier, ADHD gut connection, probiotic capsules vs powder, antibiotic recovery, gut skin axis, microbiome sleep, Firmicutes Bacteroidetes weight loss, functional medicine gut health Resources: • Get 20% off your next purchase of OMNi-BiOTiC with code ‘Dave20’ at: https://omnibioticlife.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • ...
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    56 mins
  • Give Me 21 Minutes And I'll Give You Perfect Vision Naturally : 1436

    Give Me 21 Minutes And I'll Give You Perfect Vision Naturally : 1436
    Mar 22 2026

    Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBE


    I transformed my vision from 20/80 to 20/15 by stopping the "management of decline" and starting the "restoration of tissue".


    The retina is a metabolically hungry tissue that undergoes a nightly repair program, but modern habits like screen use and late-night blue light exposure suppress the melatonin and mitochondrial energy needed for this cleanup.


    To reverse this, I use 7 specific daily habits to flip the self-healing switch:

    - Mitochondrial Fuel: I use 670 nm red light to directly fuel retinal mitochondria and increase ATP production.

    - Pigment Regeneration: I eat blueberries in the evening to accelerate night-vision pigment (rhodopsin) regeneration exactly when the eye needs it.

    - Mechanical Rest: I practice "Eye Fasting"—looking at true distance—to release the mechanical tension of constant near-focus.

    - Vascular Tone: I use a gentle cold rinse to improve vascular tone and blood flow around the eye.

    - Oxidative Stress: I practice grounding to lower systemic oxidative stress and inflammation.

    - Corneal Hydration: I use blink training to rehydrate the cornea and stabilize the protective tear film.

    - Circadian Anchoring: Finally, I watch the sunset every day to anchor my circadian rhythm, ensuring my eye's repair enzymes activate on time.


    Timestamps:

    00:00 – Intro

    01:05 – The Problem with Traditional Vision Care

    02:48 – How Your Eyes Repair Themselves at Night

    05:03 – How Modern Life Breaks the Repair Cycle

    05:53 – The 7 Habits to Activate Your Eye's Self-Healing Switch

    06:07 – Habit 1: Red Light Therapy

    07:18 – Habit 2: Blueberries and Rhodopsin

    09:22 – Habit 3: Cold Exposure for Blood Flow

    11:10 – Habit 4: Grounding to Reduce Oxidative Stress

    13:38 – Habit 5: Eye Fasting (Distance Viewing)

    15:45 – Habit 6: Deliberate Blinking

    17:53 – Habit 7: Sunset Light and Circadian Repair


    Thank you to our sponsors!

    -

    -


    Connect with Dave Asprey!


    Website: https://daveasprey.com

    TikTok: https://www.tiktok.com/@daveaspreyofficial

    Instagram: https://www.instagram.com/dave.asprey/

    Facebook: https://www.facebook.com/Daveaspreyofficial/

    X: https://x.com/daveasprey

    YouTube: https://www.youtube.com/c/daveaspreybpr


    The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/


    Danger Coffee: https://dangercoffee.com/DAVE15

    Dave Asprey’s BEYOND Conference: https://beyondconference.com/

    Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

    Upgrade Labs: https://upgradelabs.com

    40 Years of Zen: https://40yearsofzen.com

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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    21 mins
  • SNL Roasts MAHA, Pistachios Slap, ChatGPT Doctor Stats, Colon Cancer Under 50, and more... : 1435

    SNL Roasts MAHA, Pistachios Slap, ChatGPT Doctor Stats, Colon Cancer Under 50, and more... : 1435
    Mar 20 2026
    This week's stories: *SNL Roasts the MAHA Movement Saturday Night Live took direct aim at RFK-adjacent anti-vaccine culture in a sketch that lampoons raw milk, bull semen, energy healers, and "natural immunity" rhetoric — and it landed with a mainstream audience. Dave breaks down what it means when fringe health narratives become national punchlines, and why being a biohacker means staying precise about what you're actually skeptical of. Sources: -https://www.nbc.com/saturday-night-live -https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/ *Pistachios Are a Stealth Longevity Stack New Cornell-linked research shows pistachios are significantly more bioactive than standard nutrition data suggested — hitting Nrf2, AMPK, and gut barrier pathways simultaneously. This is a whole-food hack hiding in plain sight. Sources: -https://www.reddit.com/r/Biohackers/comments/1rvcqiy/cornell_university_reveals_pistachios_are_far/ -https://www.instagram.com/p/DViqesBDOZQ/ *40 Million People Are Using ChatGPT as Their Doctor Industry estimates put daily ChatGPT health queries at roughly 40 million users — making AI the largest informal primary care interface on the planet. Dave lays out the only safe framework for using these tools without getting burned. Sources: -https://www.linkedin.com/pulse/month-healthcare-ai-march-2026-gary-monk-ermcf -https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/ -https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/ *Your Microbiome Is a City — and Architecture Matters New biofilm research shows that how your gut microbes physically organize themselves may matter as much as which strains you have. The next frontier of microbiome hacking is infrastructure, not species. Sources: -https://phys.org/news/2026-01-hidden-microbial-communities-health-space.html -https://astrobiology.com/2026/03/rethinking-the-microbial-future-of-space-travel.html *Colon Cancer Is Now the Leading Cause of Cancer Death Under 50 This is no longer a retirement problem. Dave breaks down the four drivers behind the spike — and why your gut health protocols are now frontline cancer prevention. Sources: -https://pubmed.ncbi.nlm.nih.gov/41754195/ -https://www.washingtonpost.com/wellness/2026/03/03/muscle-strength-longevity-study/ *Measles Is Back — and the Math Is Unambiguous Over 1,300 confirmed cases across 31 states in 2026 alone, with the US at risk of losing its measles elimination status for the first time since 2000. Dave addresses the "natural immunity" argument directly — and doesn't pull punches. Sources: -https://www.cdc.gov/measles/cases-outbreaks.html -https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/ This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on immune resilience, gut health, microbiome optimization, cancer prevention, and how to use AI tools safely. Host Dave Asprey connects emerging science, cultural shifts, and real epidemiological data into practical frameworks you can use to build a resilient, adaptable health stack. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: MAHA movement biohacking, SNL vaccine sketch, RFK health satire, pistachios polyphenols longevity, pistachio Nrf2 AMPK, ChatGPT health advice AI, AI primary care risks, gut microbiome biofilm architecture, colon cancer under 50, colorectal cancer young adults, colon cancer prevention diet, measles outbreak 2026, measles elimination status, natural immunity measles risk, immune amnesia measles, biohacking news, longevity research 2026 Thank you to our sponsors! - Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap- The One Device | Use code DAVE for $10 off at theonedevice.com/dave Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:41 – SNL Roasts the MAHA Movement 03:20 – Pistachios and ...
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    13 mins
  • Here's Why You Still Feel Like Sh*t After Doing Everything Right... : 1434

    Here's Why You Still Feel Like Sh*t After Doing Everything Right... : 1434
    Mar 19 2026
    Your thyroid controls your energy, your metabolism, your testosterone, your mood, and your ability to think clearly. Most doctors are testing it wrong and treating it wrong, and this episode tells you exactly what to do instead. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with McCall McPherson, a physician associate, TEDx speaker, and founder of Modern Thyroid Clinic, Modern Weight Loss, and the advocacy platform Thyroid Nation. McPherson has been honored on the 2024 and 2025 Inc. 5000 lists and named a 2025 Top 500 Inc. Female Founder. She hosts the Modern Thyroid and Wellness podcast and built her entire practice around thyroid care after being failed by conventional medicine while managing her own hypothyroidism. She treats patients nationwide via telemedicine and has become one of the most trusted voices in functional medicine thyroid care. Dave and McCall expose why standard TSH-only testing catches just 1 to 2 percent of actual thyroid variation, why the medication most doctors prescribe (Synthroid/levothyroxine) fails a massive percentage of patients, and why T3 is the active hormone that mainstream medicine has been trained to fear without good reason. They also get into how fluoride in tap water, bromine in American wheat, mold exposure, dairy, gluten, and oxalates directly suppress thyroid function and drive autoimmunity. If you want to optimize your metabolism, protect your mitochondria, support brain optimization, and stop leaving your longevity on the table, thyroid is the first domino. This is essential listening for anyone serious about biohacking, human performance, anti-aging, functional medicine, supplements, sleep optimization, and using smarter not harder strategies to take control of your biology. You'll Learn: Why testing TSH alone misses thyroid dysfunction in the vast majority of people What a full thyroid panel actually includes and the optimal ranges for T4, T3, and reverse T3 Why T4-only medications like Synthroid fail and what works better How low thyroid directly tanks testosterone and libido in both men and women The environmental triggers destroying your thyroid, including fluoride, bromine, mold, and inflammatory foods How Hashimoto's connects to broader autoimmune risk and what drives it into remission Why kids are being misdiagnosed with ADHD when the real issue is hypothyroidism The supplements and cofactors (selenium, zinc, magnesium, ashwagandha, tyrosine) that support thyroid activation How thyroid optimization connects to metabolism, dementia prevention, cardiovascular health, and economic outcomes When to use T3 only vs. a T3/T4 combination, and how to know if your dose is off Thank you to our sponsors! TRU KAVA | Head to trukava.com and use code DAVE10 for 10% off. BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off https://beyondconference.com Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: McCall McPherson, Modern Thyroid Clinic, thyroid testing wrong, full thyroid panel, free T3, reverse T3, Synthroid failure, T3 vs T4, Hashimoto's remission, fluoride suppresses thyroid, thyroid low testosterone, thyroid ADHD, thyroid depression, hypothyroidism misdiagnosis, thyroid and metabolism, thyroid hair loss, functional medicine thyroid Resources: • Learn More About McCall’s Work At: https://www.modernthyroidclinic.com/ • Get McCall's Thyroid Guide: https://gift.modernthyroidclinic.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue ...
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    1 hr and 1 min
  • Hair Regrowth, Pain Relief, and Altered States — The Science Light : 1433

    Hair Regrowth, Pain Relief, and Altered States — The Science Light : 1433
    Mar 17 2026
    What if a glowing pyramid sitting in your living room could restructure your biology, compress decades of meditation into minutes, and shift your brain into an altered state without drugs, breathwork, or effort? This episode reveals the science and experience behind one of the most unusual biohacking technologies Host Dave Asprey has ever encountered. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Get $250 off from The Light System by using code ‘daveasprey’ at: https://www.thelightsystems.com/ -Find a UNIFYD Healing Center near you: https://www.unifydhealing.com/locationsJason Shurka is an author, philanthropist, and founder of Unified Healing, a global network spanning 55 countries and hundreds of wellness centers worldwide. He has written five books on health, consciousness, and human performance, and serves as the driving force behind The Light System, a technology now joined with the Gaia Network. Shurka has spent years documenting firsthand results from people around the world, making him one of the most credible independent voices on emerging light-based healing technologies. Dave Asprey and Jason Shurka break down exactly how The Light System uses full spectrum biophotonic light and encoded affirmations to create a coherent energy field that the body synchronizes with at a cellular level. They explore how this technology targets the molecular structure of water in your body, increases cellular electrical conductivity by up to 80 percent in under an hour, and creates the conditions your mitochondria need to produce more energy, accelerate recovery, and trigger deep self healing. You will learn why your body is already a light based organism, how biophotons drive biological communication at the cellular level, and why the geometry of a pyramid amplifies these effects in ways that flat screen technology cannot replicate. They also dig into the nature of consciousness, the ego as a biological operating system, and why the most powerful biohacking interventions are often the ones that work below the threshold of conscious awareness. You will Learn: Why cellular electrical conductivity increases by 80 percent after one hour of exposure to The Light System How encoded light affirmations restructure the molecular formation of water in your body without conscious effort What biophotons are and why your mitochondria, gut bacteria, and DNA are already producing and receiving them How full spectrum visible light maps directly onto the body's energy centers and organ systems Why the metamatrix font used in The Light System produces stronger biological effects than standard text How this technology was invented by a programmer combining transcendental meditation with software development What happens to your brain state when you stare at encoded light and why it resembles deep meditation without the effort How geometry, specifically the pyramid shape, amplifies photonic output and room coverage Why altered states accessed through light may be one of the most underexplored frontiers in brain optimization and neuroplasticity How to use The Light System for sleep optimization, pain relief, and cellular recovery Thank you to our sponsors! Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference Go to timeline.com/dave and save 20% with code DAVE20 STEMREGEN | Go to stemregen.co/dave30 Use code DAVE30 for 30% OFF your next order Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: The Light System, Jason Shurka, Unified Healing, Robert Religa, biophotons, metamatrix font, encoded affirmations, water structuring, electrical impedance spectroscopy, cellular conductivity, full spectrum visible light, pyramid geometry, transcendental meditation, Masaru Emoto, water crystals, morphogenic field, quantum biology, Gaia Network, Dr. Glenn Ryan, biofield, meditation technology, hair regrowth, autism light therapy, Dave Asprey, biohacking, mitochondria, smarter not harder Resources: • Get $250 off from The Light System by using code ‘daveasprey’ at: ...
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    59 mins
  • This Nobel Prize Discovery Reverses Aging In 72 Hours : 1432

    This Nobel Prize Discovery Reverses Aging In 72 Hours : 1432
    Mar 15 2026

    Is aging an inevitable decline, or just a "repair backlog" your body hasn't cleared yet?. In this episode, Dave breaks down the 2016 Nobel Prize-winning science of autophagy—the body's internal recycling system discovered by Dr. Yoshinori Ohsumi.


    Most people are stuck in a state of "biological debt," where cellular junk piles up like trash in a factory, leading to brain fog, fatigue, and chronic inflammation. Standard 16-hour fasts aren't enough to reach the deep-cleaning phase. You will learn the exact 3-day protocol to trigger a "Deep Reset," where ketones peak, inflammation falls, and stem cells wake up to rebuild your immune system from scratch.


    Join my FREE Fasting Challenge: https://daveasprey.com/fast-this-way-challenge/


    Timestamps:

    00:00 - The Anti-Aging Switch

    01:30 - Chronological vs. Biological Age

    02:32 - How Aging Works at the Cellular Level

    04:58 - 43 Ways to Upgrade Your Mitochondria

    07:37 - What Is Autophagy

    09:17 - The Stages of Fasting

    10:46 - What Happens During a 3-Day Fast

    13:04 - How to Fast Correctly

    14:42 - Breaking the Fast

    15:58 - The Power of Subtraction


    Thank you to our sponsors!

    -KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off

    -Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/


    Connect with Dave Asprey!


    Website: https://daveasprey.com

    TikTok: https://www.tiktok.com/@daveaspreyofficial

    Instagram: https://www.instagram.com/dave.asprey/

    Facebook: https://www.facebook.com/Daveaspreyofficial/

    X: https://x.com/daveasprey

    YouTube: https://www.youtube.com/c/daveaspreybpr


    The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/


    Danger Coffee: https://dangercoffee.com/DAVE15

    Dave Asprey’s BEYOND Conference: https://beyondconference.com/

    Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

    Upgrade Labs: https://upgradelabs.com

    40 Years of Zen: https://40yearsofzen.com

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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    17 mins
  • Your Telomeres Are a Lie, Bats Beat Aging, Sleep Meds Ruin Mornings, CO's Silent Kill, and more... : 1431

    Your Telomeres Are a Lie, Bats Beat Aging, Sleep Meds Ruin Mornings, CO's Silent Kill, and more... : 1431
    Mar 13 2026
    This week’s stories: Smartphone App Catches What Sleep Trackers Miss A 2026 trial found that suvorexant, a popular prescription sleep drug, improves sleep quality scores — but worsens morning alertness and cognitive function while improving afternoon and evening performance. The study used a smartphone app to pulse users throughout the day, revealing a split-time-of-day signal that traditional sleep scales miss entirely. Optimizing your sleep dashboard and optimizing your waking performance are not the same thing. Sources: https://jamanetwork.com/journals/jama/fullarticle/suvorexant-ema-trial-2026 https://www.ncbi.nlm.nih.gov/pmc/articles/suvorexant-daytime-performance Bats Are Breaking the Telomere Model A 2026 bioRxiv preprint on the tropical bat species Molossus molossus found that these animals live unusually long lives with almost no telomere shortening — challenging the assumption that telomere erosion is a universal driver of mammalian aging. Instead, the bats maintain genome integrity through superior DNA repair and oxidative stress management driven by the metabolic demands of flight. Telomere length may be a symptom, not the cause — and the longevity industry has been measuring the wrong thing. Sources: https://www.biorxiv.org/content/molossus-molossus-telomere-longevity-2026 https://www.nature.com/articles/telomere-bat-aging-2026 The Fenugreek Hack That Cuts Glucose Spikes by Up to 20% Soaking fenugreek seeds overnight and consuming them before meals has been shown across multiple small human trials to reduce fasting glucose and post-meal glucose spikes by 5 to 20 percent. The mechanism is dual — soluble galactomannan fibers slow carbohydrate absorption while bioactive compounds improve insulin receptor sensitivity in muscle and liver. It's a cheap, food-grade, CGM-trackable lever that most people have never tried. Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/fenugreek-glucose-clinical-review https://pubmed.ncbi.nlm.nih.gov/fenugreek-insulin-sensitivity-trial The First Longevity Supplement to Move Vascular Age Like Exercise A randomized, double-blind, placebo-controlled trial out of the University of Surrey found that a multi-ingredient longevity stack targeting NAD metabolism, glycation control, and mitochondrial function improved three independent vascular aging markers simultaneously in healthy adults over 40. Arterial stiffness improved by 1.18 meters per second — equivalent to reversing roughly a decade of age-related decline. Blood pressure dropped 6.1 millimeters of mercury, outperforming aerobic exercise, HIIT, the DASH diet, omega-3s, and magnesium in head-to-head comparisons. Sources: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6241278 https://clinicaltrials.gov/study/NCT06145087 https://novoslabs.com/blog/supplements/novos-core-clinical-trial-results-longevity-supplement https://www.medicalnewstoday.com/articles/longevity-supplement-improves-vascular-aging-markers-clinical-trial-novos-magnesium-gi Carbon Monoxide Exposure Is Up 50% in 2026 — And Most People Won't Know Until It's Too Late Maryland state data reported by CBS News shows emergency room and urgent care visits for carbon monoxide exposure jumped from 167 cases in 2025 to 251 so far in 2026 — a nearly 50 percent increase. CO binds to hemoglobin more tightly than oxygen, quietly starving your brain, heart, and muscles while producing symptoms that mimic fatigue, brain fog, and the flu. The CDC estimates more than 400 Americans die from unintentional CO poisoning every year — and most of them never saw it coming. Sources: https://kffhealthnews.org/morning-briefing/friday-march-6-2026 https://www.cdc.gov/niosh/topics/co/default.html https://www.cbsnews.com/news/carbon-monoxide-exposure-maryland-spike-2026 Fat Plus Carbs Around Training May Actually Be the Metabolic Move A 2026 study found that combining fat with a carbohydrate-rich period during or around exercise improves insulin sensitivity and fat oxidation in the recovery phase — directly challenging the long-held "never stack fat and carbs" rule. The mechanism appears to be a mixed-fuel training effect: the liver and muscle learn to manage glucose and fat concurrently when both are present during high metabolic demand. Context changes the calculus, and the workout itself may be the variable that flips the equation. Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/fat-carb-exercise-metabolism-2026 https://pubmed.ncbi.nlm.nih.gov/fat-carbohydrate-insulin-sensitivity-training All source links are provided for direct access to the original reporting and research. This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts ...
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    13 mins
  • Your Penis Is a Longevity Organ (Here's How to Hack It) : 1430

    Your Penis Is a Longevity Organ (Here's How to Hack It) : 1430
    Mar 12 2026
    Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Justin Houman, a nationally recognized urologist and Assistant Professor of Urology at Cedars-Sinai Medical Center. Fellowship-trained and specializing in men's health, male fertility, and sexual medicine, Dr. Houman combines cutting-edge medical advancements with holistic lifestyle strategies to help men optimize testosterone, sexual health, and reproductive performance at every age. Together, Dave and Dr. Houman tear through the myths, the bad science, and the outdated medical dogma around testosterone, erectile function, fertility, and male sexual health. They cover everything from why testosterone levels have collapsed in a single generation, to the real story behind the FDA black box warning, to practical protocols for men who want to optimize without sacrificing fertility. This is the masterclass on men's health that no one else is having on record. This is essential listening for anyone serious about biohacking, longevity, human performance, hormone optimization, brain optimization, anti-aging, functional medicine, mitochondria, and Smarter Not Harder approaches to male health. You'll Learn: Why testosterone levels in 40-year-old men are 30 percent lower than their fathers and what is driving the collapse How low testosterone connects to anxiety, depression, high cholesterol, blood sugar dysregulation, and all-cause mortality risk The truth about the original testosterone and heart attack study and why it still has not been retracted How to preserve fertility while on TRT using Clomid, enclomiphene, and HCG Why daily low-dose Cialis is one of the cheapest and most effective longevity drugs available What shockwave therapy, PRP, exosomes, and Botox injections actually do for erectile function How red light therapy at 660 and 850 nanometers supports testosterone production and nocturnal erections The supplement stack including ashwagandha, tongkat ali, fadogia agrestis, and creatine that supports healthy hormone levels Why porn-induced ED is epidemic in young men and how to reverse it How PT-141 and peptides fit into a complete male optimization protocol Thank you to our sponsors! Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.Establish a powerful foundation for sustained wellness with Pique. Unlock 20% off: piquelife.com/DAVE BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: testosterone, low testosterone, TRT, testosterone replacement therapy, male fertility, erectile dysfunction, ED, men's health, sexual health, hormone optimization, Dave Asprey, biohacking, longevity, anti-aging, human performance, Dr. Justin Houman, Cedars-Sinai, urologist, shockwave therapy, PRP, exosomes, Botox penis, red light therapy, nitric oxide, Cialis, tadalafil, Viagra, sildenafil, PT-141, Melanotan, peptides, ashwagandha, tongkat ali, fadogia agrestis, creatine, Danger Coffee, Smarter Not Harder, Kyzatrex, clomid, enclomiphene, HCG, prolactin, cabergoline, porn-induced ED, refractory period, fertility, sperm health, spermatogenesis, FSH, LH, estrogen, aromatization, functional medicine, supplements, mitochondria, circadian rhythm, sleep optimization, cortisol, microplastics, inflammation, cardiovascular health, dementia, all-cause mortality, nocturnal erections, penile health, male optimization Resources: • Learn More About Dr. Houman’s Work At: https://houmanmd.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark...
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    1 hr and 3 mins